The difference disappeared within 30 days of discontinuing treatment. Mean serum uric acid concentrations decreased after treatment was stopped. The increases typically did not progress with ongoing treatment and often decreased with continued therapy. Evidence of reversibility upon discontinuation was observed even in those with the greatest on treatment increases. Treatment groups in PLATO did not differ for renal-related serious adverse events such as acute renal failure, chronic renal failure, toxic nephropathy, or oliguria.
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Instances of serious bleeding, such as internal bleeding, may require blood transfusions or surgery. Bleeding will also take longer than usual to stop. Call your doctor right away if you have any signs or symptoms of bleeding while taking BRILINTA, including: severe, uncontrollable bleeding; pink, red, or brown urine; vomit that is bloody or looks like coffee grounds; red or black stool; or if you cough up blood or blood clots.
People who are treated with a stent, and stop taking BRILINTA too soon, have a higher risk of getting a blood clot in the stent, having a heart attack, or dying.
Tell your doctor if you take other medicines that contain aspirin. Do not take new medicines that contain aspirin. Call your doctor if you have new or unexpected shortness of breath or any side effect that bothers you or that does not go away. Your doctor can decide what treatment is needed. Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Tell your doctor if you are breastfeeding or plan to breastfeed.
BRILINTA is used with aspirin to lower your chance of having another serious problem with your heart or blood vessels such as heart attack, stroke, or blood clots in your stent if you received one. These can be fatal. You may report side effects related to AstraZeneca products by clicking here. The information on this Web site should not take the place of talking with your doctor or health care professional.