BARRIERE HEMATO ENCEPHALIQUE PDF

Vukinos This approach bemato more on the field control and less on the cellular microenvironment. American Journal of Pathology. A significant amount of research in this area has been spent exploring methods of nanoparticle-mediated delivery of antineoplastic drugs to tumors in hsmato central nervous system. A brain abscess may also be caused by head trauma or as a complication of surgery. This approach has been standardized for clinical use.

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Buclin J. Biollaz Rev Med Suisse ; volume 1. The blood-brain barrier : An overview : Structure, regulation, and clinical implications. Neurobiol Dis ; The factors that influence permeation across the blood-brain barrier. Eur J Med Chem ; Modulation of drug transporters at the blood-brain barrier. Pharmacology ; Blood-brain barrier efflux transport. J Pharm Sci ; Disruption of the mouse MDR1a P-Glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs.

Cell ; ABC transporters and the blood-brain barrier. Curr Pharm Des ; The impact of efflux transporters in the brain on the development of drugs for CNS disorders. Clin Pharmacokinet ; Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene.

Pharmacogenetics ; Clin Pharmacol Ther ; A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression. Pharmacogenomics J ; Pharmacogenetics ; Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1.

N Engl J Med ; Clin Pharmacol Ther ; Blood-brain barrier drug targeting : The future of brain drug development. Mol Interv ; Adv Drug Deliv Rev ; Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting : Implications of the barriers between blood and brain.

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