For instance, indometacin inhibits both cyclooxygenase-1 and cyclooxygenase-2 , which then inhibits the production of prostaglandins in the stomach and intestines responsible for maintaining the mucous lining of the gastrointestinal tract. Indometacin, therefore, like other non-selective COX inhibitors can cause peptic ulcers. It should always be taken with food. Nearly all patients benefit from an ulcer protective drug e.
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Clin Obstet Gynecol. Indomethacin therapy in the treatment of symptomatic polyhydramnios. Moise KJ Jr 1. It appears that maternal indomethacin therapy may be a useful adjunct in selected cases of polyhydramnios.
Initial evaluation should include glucose tolerance testing and a thorough search for fetal abnormalities by ultrasonography.
In the patient with symptoms such as premature labor or respiratory compromise, an initial amniocentesis should be considered for decompression and fetal karotype.
Oral indomethacin therapy can then be started. Although the optimal dose is unknown, a mg oral dose every 6 hours appears adequate. Ultrasound assessment of amniotic fluid volume should be done once or twice weekly. If oligohydramnios develops, the indomethacin should be discontinued, and the amniotic fluid volume serially monitored. Fetal echocardiography should be considered in the first 24 hours after therapy has been initiated and weekly thereafter. Evidence of severe constriction of the ductus arteriosus or tricuspid regurgitation warrants discontinuation of the indomethacin; lesser degrees of ductal constriction can be treated by decreasing the dose of the medication.
Indomethacin therapy in the treatment of symptomatic polyhydramnios.
Shakamuro We linked 15, singleton pregnancies with premature rupture of membranes from a nationwide US obstetrics cohort to local temperature. PPROM before 26 weeks has a high morbidity and mortality, and the significant predictors of neonatal mortality and adverse outcomes were antibiotic prophylaxis, latency period, GA at birth and polihidrambios weight. Factor de von Willebrand. The similarities and differences underlying cervical remodeling in premature prelabor rupture of fetal membranes and spontaneous preterm labor with intact membranes are unexplored. Preterm infants exposed to severe chorioamnionitis had an increased risk of brain injury. Primary complication for mother is infection and for foetus and neonate is prematurityfoetal distress, cord compression, deformation, pulmonary hypoplasia, necrotising enterocolitis and neurologic disorders.